Want to Stimulate Collagen? Should You Choose Sculptra or Skin Boosters Like Profhilo and Definisse Hydrobooster?

SPARK IDEA Digital Marketing
May 26
27 min read

Hello everyone! I'm Dr. Nono, Dr. Chanapat Chinwejkijkwanich (Medical License No. 60686), from Entrio Clinic, an aesthetic medical clinic in the heart of Ratchaprasong. I'm delighted to once again delve into the topic of beautiful skin in a way that we truly "know" and "understand" deeply. Today, we'll expand on and understand the details of innovations that are highly discussed in the beauty industry, especially the group of Biostimulators or collagen-stimulating substances, which are essential for rejuvenating the skin from within. And of course, the clear answer many of you are looking for is: "If I want to stimulate collagen, should I choose Sculptra, or skin boosters like Profhilo or Definisse Hydrobooster?"

As a doctor at Entrio Clinic, an aesthetic clinic in Ratchaprasong, I believe that having accurate and detailed information will help you decide what is "right" for your skin. Today, I'll take you deep into the properties, mechanisms of action, and differences between Sculptra, Profhilo, and Definisse Hydrobooster, from my own perspective, so you can truly visualize and understand each one's role in collagen stimulation and which one will best meet your needs.

Understanding Biostimulators: Not Just "Filling," but "Awakening Your Own Collagen Production"

Many of you who have heard of Biostimulators or collagen-stimulating substances might still be confused about what they actually are. Are they like fillers? Or lifting devices? Today, Dr. Nono will take you to "know deeply, know truly" about the fascinating mechanism of Biostimulators.

Imagine this: when our skin starts showing signs of aging, such as sagging, wrinkles, and volume loss, it's partly because our "production factories" for collagen, elastin, and HA—which are Fibroblast cells—start to slow down and become less efficient. It's like an old factory machine whose production capacity is no longer at its peak. What we see on the outside is a skin "building" that starts to deteriorate, with a weakened structure.

In the past, a common solution was using Dermal Fillers. Most fillers, such as Hyaluronic Acid fillers, are like bringing in "prefabricated construction materials" to "fill" sunken areas or to "support" weakened structures. When filler is injected into a specific spot, that area immediately looks fuller, or wrinkles appear shallower. The results are quick and immediate. This is comparable to "repairing" damaged parts of a building by bringing in "bricks" or "cement" to fill gaps or reinforce foundations. This is a "symptomatic" solution that focuses on "filling" with external substances. Fillers are good and necessary in many cases, especially when quick and precise results are desired for facial contouring or localized volume enhancement.

But Biostimulators are different. The core of a Biostimulator is to "stimulate." Stimulate what? It stimulates our very own Fibroblast cells!

Biostimulators do not directly "fill" lost tissue immediately like fillers. Instead, they act like a "signal" or a "premium raw material" that, once injected into the skin layers, sends a message to dormant Fibroblast cells, telling them to "wake up" and work actively again. It's like "restarting" our collagen production factory to run at full capacity.

The Fascinating Mechanism of Biostimulators: How Do They "Awaken" and Create?

When a Biostimulator is injected into the skin layer (by an expert physician, as the appropriate layer must be chosen for each Biostimulator), what happens is:

Tissue Recognition and Response: The body recognizes the "substance" (Biostimulator) that has entered the skin layer. This substance is safe and highly compatible with the body.
Creating an Environment Conducive to Stimulation: Some Biostimulators (like Sculptra, which consists of tiny particles) create a microscopic environment within the tissue that attracts and stimulates various cells, especially Fibroblasts.
Direct Signaling to Fibroblasts: The active ingredients in the Biostimulator send signals directly to the Fibroblast cells through their cellular communication pathways. It's like flipping an "on" switch or "activating" them. These signals stimulate Fibroblasts, which might normally be underperforming due to age or other factors, to proliferate (increase in number) and activate (increase in activity).
The "Production Factory" is Back at Full Capacity: New Collagen, Elastin, and HA are Created!: Once Fibroblasts are fully stimulated, they begin the process of synthesis and secretion of essential substances that form the skin's structure. The most important thing they create anew is Collagen (especially Collagen Type I and Type III), which is the primary collagen that provides strength and elasticity in youth. In addition, they also stimulate the production of Elastin, which restores skin elasticity, and Hyaluronic Acid (HA), which provides hydration and volume. This process of new collagen formation is called Neo-collagenesis, and the formation of new elastin is called Elastogenesis. This is the core! Biostimulators do not introduce pre-made collagen from outside; instead, they stimulate your own body to produce new collagen and elastin!
Remodeling the Extracellular Matrix (ECM): Besides collagen, elastin, and HA, Fibroblasts also produce other components of the ECM, which is the foundational structure supporting skin cells. When Biostimulators stimulate Fibroblasts, they essentially "remodel the skin structure" at a deeper level. This results in the overall skin structure becoming stronger, more organized, and functioning better.

Biostimulators vs. Fillers: Different Mechanisms, Different Results!

To illustrate the difference more clearly, let's compare the mechanism of Biostimulators with Fillers again, using the analogy of building structures:

Dermal Filler: It's like bringing in "bricks" or "cement" that are already manufactured from outside to "fill" gaps or reinforce weakened parts of a building immediately. The results are quick, and it's good for specific problem areas.

Biostimulator: It's like "building a new brick factory" in the desired area and "awakening" the workers (Fibroblasts) to start "producing bricks" (collagen, elastin) continuously on their own. These are then used to "repair and strengthen the building's structure" from within.

Results from "Awakening Your Own Production Power": Natural, Long-lasting, and More Than Just Volume!

Since the true results of Biostimulators come from the body "creating" its own collagen and elastin, this process takes time.

Gradual Results: You won't see immediate changes right after injecting a Biostimulator. Instead, you'll start noticing subtle changes over several weeks, and they will gradually become more apparent until the full effect is seen in several months (depending on the type of Biostimulator and individual response).

Extremely Natural-Looking Results: This is a key advantage. Because the volume or firmness achieved comes from your body's own tissue (collagen, elastin, HA), it blends seamlessly with your skin, looking completely natural, not lumpy or "done." It's like your skin genuinely looks younger on its own!

Long-Lasting Results: Since it's a stimulation for the body to create new skin structures, the results from Biostimulators last longer than typical fillers, generally from 1 year up to 2 years or even more (depending on the type of Biostimulator and other factors). This is a worthwhile investment in long-term skin health.

Gradual Improvement, Getting Better Over Time: You won't see dramatic immediate changes after the injection. You might see a small volume from the water used for mixing, which will be absorbed within a few days. However, the results from collagen production will gradually appear over 1-2 months and reach their full effect in 3-6 months after the injection, making the changes appear very natural.

Various Types of Biostimulators... But the Principle of "Awakening Your Own Production Power" is Key.

While there are many types and brands of Biostimulators, each with different active ingredients (such as PLLA in Sculptra, HA Complex in Profhilo, HA + Glycerol in Definisse Hydrobooster, PDLLA + HA in Juvelook), and these differences make each type unique and suitable for different problems (which we will delve into for each product), the fundamental principle at their core is to "stimulate" Fibroblast cells to produce new collagen and elastin on their own!

At Entrio Clinic, an aesthetic clinic in Ratchaprasong, my team and I deeply understand the importance of this mechanism. We prioritize using standard-certified Biostimulators and possess extensive knowledge of each type's mechanism of action to effectively "awaken your skin's own production power" and deliver truly natural and long-lasting youthful skin results.

Understanding that Biostimulators are not just about "filling" but about "awakening your own production power" will help you gain a correct overview of how to care for aging skin. It will also show you why investing in Biostimulators is a worthwhile investment for long-term skin health.

Sculptra: The Ultimate Biostimulator... Focused on Building Volume and Skin Structure from Within, Sustainably

Sculptra is not just an ordinary aesthetic injectable; it's an innovation that acts like a clever "architect," helping to "design" and "build" your skin's structure from within, naturally and sustainably!

With its outstanding ability to emphasize lost volume restoration and rejuvenate skin structure for firmness, Sculptra is the answer for many who desire results beyond temporary fixes.

Deep Dive into Sculptra's Active Ingredient and Mechanism: "Poly-L-Lactic Acid (PLLA)" - The Builder of Structural Power

The core reason why Sculptra is special and different from other Biostimulators or common fillers is its key ingredient: Poly-L-Lactic Acid (PLLA).

What is PLLA?

PLLA is a synthetic polymer that has received safety standard certifications and has been used in the medical field for many decades. For example, it's used in dissolvable sutures or materials for bone surgery. Therefore, its biocompatibility with the body is assured.

What form does PLLA take in Sculptra?

PLLA in Sculptra is not in the form of a gel or clear liquid like typical fillers. Instead, it comes in the form of very tiny microparticles. When preparing for use, a physician will mix these small PLLA powder particles with sterile water for injection to prepare them before the procedure.

Mechanism of Action: More than just stimulation, it's about "creating" new structures!

When a physician injects Sculptra, containing these PLLA microparticles, into the deep dermis or subcutaneous layer in areas requiring correction, such as areas with volume loss or those needing structural enhancement, what happens is that these PLLA particles settle within the tissue.

The PLLA particles perform two main functions. Firstly, they act like tiny "scaffolds" that allow various tissue cells, including Fibroblast cells, to attach to them. Secondly, the PLLA particles stimulate a cellular response, specifically activating Fibroblast cells, our "collagen production factories," to work actively and proliferate (increase in number).

And a very significant advantage of Sculptra is its ability to stimulate Fibroblasts to "create new collagen," primarily focusing on Collagen Type I. Why emphasize Type I? As we've learned, Collagen Type I is the most abundant type of collagen in the skin and is the main collagen that provides strength, volume, and structure to youthful skin. Sculptra's ability to stimulate a large amount of Type I collagen makes it outstanding in restoring lost volume and genuinely strengthening weakened skin structures.

The PLLA particles in Sculptra do not remain in our bodies indefinitely; they gradually biodegrade naturally over several months (approximately 6-12 months). However, it's during this gradual degradation that they continuously stimulate the creation of new collagen. Once the PLLA has completely degraded, what remains is the strong new Collagen Type I structure that our body has created itself.

Difference from conventional fillers

This mechanism clearly differs from common fillers. Most fillers simply "fill" voids immediately with external substances (mostly HA). Sculptra, however, "stimulates" the body to produce its own tissue (collagen).

Sculptra's Outstanding Results: Natural Volume, Strong Structure... Lasting Long!

Due to its unique mechanism of action, Sculptra delivers distinct and impressive results.

Natural and Harmonious Volume Creation: Because the volume achieved comes from your body's own collagen production, the process is gradual over several months. The results are therefore very natural, blending seamlessly with your own skin. No one will know you've had anything done, but they will notice you look younger and your face appears fuller, less tired. It doesn't look lumpy or appear "done."

Sustainable Internal Skin Structure Rejuvenation: Sculptra's ability to stimulate the production of Type I collagen, which is the main structural component, leads to overall stronger, firmer, and more elastic skin. This is a root cause solution, not just a superficial fix.

Long-Lasting Results: Because the changes are a result of the body's new collagen production, Sculptra's results typically last longer than conventional fillers, averaging 1-2 years, or in some cases, even more than 2 years. This makes it a very worthwhile long-term investment for your skin.

Gradual Improvement, Getting Better Over Time: You won't see immediate dramatic changes right after the injection. You might notice a small amount of volume from the water used for mixing, which will be absorbed within a few days. However, the results from collagen production will gradually appear within 1-2 months and reach their full effect within 3-6 months after the injection, making the changes appear very natural.

Who is Sculptra suitable for?

With its outstanding properties, Sculptra is ideally suited for individuals with the following concerns:

Those with clear facial volume loss, such as hollow cheeks, sunken temples, deep under-eye hollows, or a tired-looking face lacking fullness.
Those who wish to rejuvenate skin structure to restore long-term strength, firmness, and elasticity.
Those who desire very natural-looking results where no one knows they've had anything done, but they feel they look better and younger.
Those who can wait for the results to gradually appear over several months.
Those who want an investment in their skin that yields long-lasting results.

Popular Areas for Sculptra Treatment

Sculptra can be injected into various areas of the face and body to restore volume and skin structure.

Temples: Addresses hollow temples, making the face appear more balanced and youthful.
Cheeks: Especially in areas where tissue has sunken, it helps to plump up the cheeks and provides a subtle lift.
Jawline: Helps to enhance definition, creating a more sculpted jawline.
Overall Face: Used in injection techniques aimed at comprehensive skin structure rejuvenation.
Other areas: Such as nasolabial folds and marionette lines (may be injected around these areas to provide structural support and lift, depending on physician assessment), or the neck and hands (depending on physician assessment and technique).

Sculptra Treatment Steps at Entrio Clinic Ratchaprasong (by Expert Physician)

Performing Sculptra is a procedure that must be carried out by an experienced physician who thoroughly understands its mechanism of action. At Entrio Clinic Ratchaprasong, we prioritize every step.

Consultation and Assessment: The physician will meticulously assess your skin condition, the issues you wish to address, and your expectations. This allows for a comprehensive treatment plan, including determining the number of vials and the specific areas for injection.
Sculptra Preparation: Sculptra must be reconstituted with sterile water for injection in advance, following the manufacturer's recommendations. This preparation may take several hours to several days to achieve the appropriate concentration before injection.
Topical Anesthesia: A topical anesthetic cream will be applied to the injection area to minimize discomfort during the procedure.
Sculptra Injection: The physician will inject Sculptra into the appropriate skin layer using precise and accurate injection techniques. This ensures that the PLLA disperses effectively and stimulates collagen production efficiently.
Post-Injection Massage: The physician will immediately massage the injected area and instruct the patient to continue self-massaging at home according to strict instructions (the 5x5x5 rule: massage for 5 minutes, 5 times a day, for 5 consecutive days). This massage helps to ensure proper PLLA distribution and reduces the risk of nodule formation.
Follow-up: The physician will schedule follow-up appointments to monitor your progress and may consider additional injections at a later stage to achieve complete results (multiple sessions are often required to stimulate a sufficient amount of collagen).

Things to Know and Limitations of Sculptra

Results are not immediate: You need to be patient as it takes time to see the full results.
Requires physician expertise: The preparation of the product, the injection technique, and the selection of appropriate areas are extremely important.
May cause nodules: If injected into the wrong layer or if post-injection massage is insufficient (however, the risk is very low when performed by an experienced physician).
Not suitable for treating superficial wrinkles or epidermal problems: Sculptra is more suited for addressing volume loss and deeper structural issues.
May require multiple sessions: To achieve clear and sufficient collagen stimulation results.

The Group of "Skin Boosters" with Collagen-Stimulating Properties: Profhilo and Definisse Hydrobooster... Emphasizing "Skin Quality" and "Hydration" with Supplemental Collagen Stimulation

After we've understood what Biostimulators are, how they differ from traditional fillers, and delved into Sculptra, which excels at creating volume and structure, today we will "deep dive" into another important group of Biostimulators that I highly prioritize at Entrio Clinic, an aesthetic clinic in Ratchaprasong. This is the group of "skin boosters" with collagen-stimulating properties. The representatives we will get to know in detail today are Profhilo and Definisse Hydrobooster.

This group doesn't focus on creating significant volume like Sculptra, but its strength lies in emphasizing "skin quality" and "hydration," along with stimulating collagen in the skin layers. This approach aims to improve skin from within, in another dimension. It's like taking care of the "surface" and "true essence" of the skin's "building" to make it more beautiful and stronger.

Profhilo: The Biostimulator for Skin Quality... Plump, Firm, Glowing from Within

Profhilo is not just a general aesthetic procedure. Instead, it is a "deep structural skin nourishment" that genuinely "resets" and "rejuvenates your skin quality" from within. With its unique mechanism and results that focus on radiance, plumpness, and overall skin health, Profhilo is the answer for many who desire an overall natural improvement in their skin, without wanting significant facial reshaping.

Deep Dive into Profhilo's Unique Active Ingredient and Mechanism: "HA Complex" of High Purity... The Awakener of Skin Quality!

The uniqueness of Profhilo begins with its active ingredient.

Active Ingredient: 100% Highly Pure, "Non"-Cross-linked Hyaluronic Acid (HA) Complex, unlike conventional fillers. The main active ingredient is Hyaluronic Acid, or HA, a natural substance found in our skin that plays a vital role in water retention and hydration. However, the HA in Profhilo is fundamentally different from the HA found in conventional Dermal Fillers.

The HA in Profhilo is 100% highly pure, and most importantly, it does not undergo "cross-linking," which is the process of linking molecules into a stable network like in conventional HA fillers used for volume augmentation.

Profhilo utilizes a special manufacturing technology called Bio-compatible Thermal Cross-linking, which uses heat to link two sizes of HA molecules (High-molecular-weight and Low-molecular-weight HA) together. This process creates an HA Complex with unique properties: it has very low viscosity (unlike fillers, which have high viscosity), and most importantly, this HA Complex retains excellent Biostimulator properties.

The concentration of HA in Profhilo is also very high, containing 64 milligrams of HA in 2 milliliters, which is several times higher than conventional HA fillers or skinboosters.

In-depth Mechanism: Rapid Dispersion... Towards "Resetting" and "Remodeling" the Dermal Layer!

Thanks to its properties as an HA Complex with low viscosity and non-cross-linked structure, when a physician injects Profhilo into the dermis using a specific technique called BAP (Bio Aesthetic Point) Technique—which involves injecting only 5 points per half-face (10 points across the entire face) that have been precisely calculated to be safe and allow the substance to disperse effectively over the widest area—what happens is that the injected HA Complex does not remain as a concentrated lump at the injection site like traditional fillers. Instead, it disperses rapidly and uniformly throughout the dermis and surrounding layers in the treated area. It's like injecting a high-quality "hydrogel" that gradually permeates and spreads throughout the skin's "sponge."

This widespread dispersion of the high-concentration HA Complex throughout the skin is the crucial key that "signals" and "stimulates" Fibroblast cells to work at full capacity!

The HA Complex interacts with various components of the skin tissue, and importantly, it binds to receptors on the surface of Fibroblast cells. This causes these cells to be "awakened," "proliferate (increase in number)" more, and "activate (increase in activity)" in producing essential substances.

The essential substances that Fibroblasts create anew from Profhilo's stimulation are collagen (especially Type I and Type III), which provide strength and elasticity; elastin, which restores skin resilience; and, crucially, Hyaluronic Acid (HA) produced by the body itself (Endogenous HA). Profhilo's ability to stimulate the production of all three of these essential substances directly in the dermis constitutes a "complete dermal remodeling." It's not just about filling, but about "creating the true essence" of the skin anew, making the overall skin structure stronger, more elastic, and functioning more efficiently.

Profhilo's Outstanding Results: More than just "Filling," It's "Youthful Skin" in a New Dimension!

Due to its unique mechanism of action, Profhilo delivers results that primarily focus on "skin quality," which differs from Sculptra's emphasis on volume and structure, or conventional fillers' focus on localized augmentation. Profhilo's results will make the skin look better from within, naturally.

Intense Hydration and "Hydro Effect" / "Glass Skin" With the very high concentration of HA Complex and its widespread dispersion, Profhilo effectively draws water into the skin layers, providing deep hydration. The result is skin that looks plump, firm, and dewy, like "Glass Skin." Truly hydrated skin will appear radiant, and fine lines caused by dehydration will visibly diminish.

Improvement in Skin Firmness and "Lifting Effect" from Skin Quality Although Profhilo does not focus on deep structural lifting like high-energy devices such as Ultherapy or Oligio, its stimulation of new collagen and elastin production in the dermis significantly helps to improve overall skin firmness. Many people will feel a subtle, natural lift, which is a result of the stronger and more elastic skin structure in the dermis.

Enhanced Elasticity: Skin Looks More Resilient and Bouncy Stimulating new elastin production improves skin elasticity. The skin will appear bouncier, less prone to creasing, and will return to its original shape better after facial expressions.

Improved Radiance and "Glow": Clear, Radiant, Aura-like Skin Skin that is deeply hydrated and has an improved structure from new collagen and elastin production will appear healthier with better circulation, making the skin look brighter, radiant, and with a natural aura.

Reduction in Fine Lines and Crepiness: Smoother Skin, Finer Wrinkles Diminish Skin that is plump, firm, and more elastic due to Profhilo will appear smoother, and fine lines, especially those caused by dehydration or reduced elasticity, will visibly diminish.

Improved Skin Texture and Smoothness: Refined Skin Surface Remodeling the dermal layer to be stronger and more organized also contributes to a smoother overall skin surface.

Very Natural-Looking Results Because the results come from rejuvenating your own skin structure, the process is gradual and focuses on overall skin quality. The results appear very natural.

Who is Profhilo Suitable for?

With its unique properties, Profhilo is ideally suited for individuals with these concerns and desired outcomes:

Those with dry, dehydrated skin that looks dull and lacks radiance.
Those with tired-looking skin that lacks vitality.
Those who feel their skin is starting to lose elasticity and firmness, and are beginning to notice fine lines across their face.
Those who want to improve overall skin quality to look healthier, plumper, and more radiant naturally.
Those who want to stimulate collagen and elastin in the skin effectively.
Those who do not desire significant volume augmentation or dramatic facial reshaping.
Those who prefer a procedure with fewer injection points, feeling more comfortable during treatment (compared to widespread facial injections).

Popular Areas for Profhilo Treatment:

Profhilo can be injected into various areas that require skin quality rejuvenation.

Full Face: Using the BAP technique of 5 points per half-face (10 points total), which is designed to effectively spread the HA Complex across the entire face.
Neck: Helps rejuvenate the skin on the neck that suffers from crepiness, loss of elasticity, and wrinkles.
Back of Hands: Helps rejuvenate the skin on the back of the hands, which often shows signs of dryness, wrinkles, and thinning.
Upper Arms: Helps rejuvenate the skin on the upper arms that may have issues with laxity and uneven texture.

Profhilo Program at Entrio Clinic Ratchaprasong:

Generally, for optimal results, Profhilo is often recommended as a course of treatments.

Standard Program: Typically, 2 sessions, 1 month apart, are recommended to ensure continuous and sufficient stimulation of collagen, elastin, and HA.

Maintenance Treatment: After the initial 2 sessions, it is recommended to repeat the treatment every 6-12 months to maintain good skin condition and slow down the natural aging process.

Things to Know About Profhilo:

No significant volume enhancement: Profhilo is not a filler designed for volume augmentation to reshape the face.
Requires correct injection technique: Injecting with the BAP technique and into the appropriate skin layer is crucial for Profhilo to spread well and deliver desired results.
May have small bumps after injection: In some injection spots, small bumps similar to mosquito bites may appear, which will gradually subside and disappear within 2-3 hours or a few days, depending on individual skin response.

Profhilo is a truly outstanding Biostimulator in terms of "skin quality." It "awakens your own production power" to create collagen, elastin, and HA effectively, making the overall skin look plump, hydrated, firm, and radiant from within. It's a very natural approach to skin rejuvenation.

If you are looking to address dry, tired-looking skin that lacks radiance, are starting to notice fine lines, or want to improve overall skin health naturally, the Profhilo Program at Entrio Clinic, an aesthetic clinic in Ratchaprasong, is an excellent choice.

Definisse Hydrobooster: High-Quality Skinbooster with Additional Collagen-Stimulating Properties

After we've delved into Sculptra, which focuses on creating volume and structure, and Profhilo, which emphasizes overall skin quality rejuvenation, today we will get to know another fascinating innovation in the "skin booster" category that stands out for its "hydration" properties along with its "supplemental collagen stimulation" – that is, Definisse Hydrobooster. It is not just a typical skinbooster; it is a "high-quality skinbooster that offers more than just hydration," by adding the ability to stimulate collagen production. This makes it a very attractive option for those whose primary concern is dry, dehydrated skin that looks dull and has fine lines.

Deep Dive into Definisse Hydrobooster's Active Ingredients and Mechanism: HA + Glycerol... The Duo of Hydration and Supplemental Stimulation!

The uniqueness of Definisse Hydrobooster lies in its composition and mechanism of action, which emphasize deep hydration along with Biostimulation properties.

Active Ingredients: Non-Cross-linked Hyaluronic Acid (HA) + Glycerol

Non-Cross-linked HA: Definisse Hydrobooster contains Hyaluronic Acid, or HA, similar to conventional fillers. However, the crucial point is that the HA in Definisse Hydrobooster is "not cross-linked" or permanently linked into a network like the HA in fillers used for volume augmentation. Non-cross-linked HA has a linear molecular structure, lower viscosity, and primarily emphasizes its ability to retain water and disperse well within the skin layers. It is not designed to maintain shape and provide distinct volume, but rather to focus on hydration.

Glycerol: In addition to HA, Definisse Hydrobooster also contains Glycerol as a key component. Glycerol is a sugar alcohol compound with humectant properties, meaning it helps to draw moisture from the air and retain water within the skin layers excellently. The combination of Glycerol with non-cross-linked HA creates a synergistic effect in providing hydration, allowing Definisse Hydrobooster to deliver and retain water in the skin layers more efficiently. Glycerol may also play a role in supporting the function of the skin barrier and can influence certain cellular metabolic processes in the skin.

In-Depth Mechanism: Intense Hydration... Plus Supplemental "Collagen Stimulation"!

The most outstanding primary mechanism of Definisse Hydrobooster is deep and long-lasting hydration in the dermal layer. When injected, HA and Glycerol work to draw in and retain water, much like "watering" a parched skin layer to restore its plumpness and firmness from within. Well-hydrated skin appears radiant, vibrant, and flexible.

In addition to its primary role in hydration, Definisse Hydrobooster also has the property of stimulating Fibroblast cells to produce collagen to a certain extent. Although its collagen-stimulating ability may not be as intense as Sculptra, which focuses on volume creation, or Profhilo, which focuses on overall dermal structure rejuvenation, this property is what distinguishes Definisse Hydrobooster from other skinboosters that are purely HA-based. The collagen stimulation that occurs helps to enhance skin firmness and elasticity to a subtle degree.

Impact on Extracellular Matrix (ECM)

Definisse Hydrobooster works to improve the environment within the ECM by primarily enhancing hydration levels, leading to a better environment for cells and collagen/elastin fibers, which in turn affects cellular function and helps maintain existing skin structural integrity.

Definisse Hydrobooster's Outstanding Results: "Hydrated Skin," "Radiant Glow," and "Subtle Firmness"

From its composition and mechanism of action, Definisse Hydrobooster delivers results that focus primarily on "skin quality," particularly in terms of hydration.

Outstanding Hydration and "Glass Skin" / "Dewy Skin" This is its strongest point. The skin receives intense hydration, making it look plump, firm, radiant, and possess a dewy glow that looks healthy. Fine lines caused by dehydration immediately appear diminished.

Improvement in Skin Elasticity and Suppleness Hydrated skin gains better elasticity, feeling soft, smooth, and more pliable to the touch.

Reduction in Superficial Fine Lines With the skin receiving full hydration, it appears smoother, causing fine lines, especially those caused by dry skin, to visibly diminish.

Improved Skin Radiance and Smoothness Healthy, adequately hydrated skin exhibits improved circulation, making the skin appear brighter, smoother, and possess a natural aura.

Slight Firming Effect From both the plumping effect of hydration within the skin and the subtle collagen stimulation, a slight firming sensation may be felt.

Under-Eye Treatment with Definisse Hydrobooster: Increased Hydration, Wrinkle Reduction, and Brightening for the Eye Area

The under-eye area is particularly prone to dry skin, fine lines, and dullness due to its delicate nature and susceptibility to moisture loss. Definisse Hydrobooster can effectively nourish the under-eye skin. Its key properties, HA and Glycerol, help to:

Provide deep hydration: HA and Glycerol will help draw and retain water in the under-eye skin, making it look plumper, less dry, and reducing the appearance of small lines caused by dehydration.

Reduce fine lines: When the under-eye skin is adequately hydrated and has improved structure from stimulated collagen, fine lines caused by dehydration and reduced elasticity will appear diminished, making the under-eye area look smoother.

Brighten the eye area: Healthy, hydrated skin with improved circulation will make the under-eye area look brighter, less dull, and reduce dark circles caused by dry and tired-looking skin, helping the eyes appear more vibrant and lively.

Injecting Definisse Hydrobooster in the under-eye area helps rejuvenate overall skin quality, making the under-eye skin appear brighter, plumper, and more youthful naturally.

Who is Definisse Hydrobooster suitable for?

Definisse Hydrobooster is highly suitable for individuals who have these concerns and desire these results:

To address severe dry, dehydrated skin or to deeply hydrate the skin.
To reduce fine lines, especially those caused by dehydration.
To improve overall skin quality to appear smoother, brighter, and more elastic.
To achieve dewy skin with a natural aura.
Those who want to nourish the under-eye area to increase hydration, reduce wrinkles, and brighten the area.
Those who prefer gradual and natural-looking results.

Popular Areas for Definisse Hydrobooster Treatment Definisse Hydrobooster can be injected into areas that need increased hydration and improved skin quality.

Full Face: To restore hydration, improve overall skin condition, and reduce fine lines.
Neck: Helps to make the skin on the neck, which often suffers from dryness and wrinkles, appear plumper and smoother.
Back of Hands: Helps to make dry and wrinkled skin on the back of the hands appear plumper and firmer.
Under-eyes: Helps to increase skin hydration around the eyes, reduce dark circles, and brighten the area.

Definisse Hydrobooster Program at Entrio Clinic Ratchaprasong A course of treatment is often recommended for continuous and clear results.

Standard Program: Often recommends multiple sessions (e.g., 2-3 times or more) spaced out periodically to ensure continuous hydration and collagen stimulation.
Maintenance Treatment: Periodic repeat treatments may be considered as advised by the physician.

Things to Know About Definisse Hydrobooster:

It focuses on hydration and skin quality, not on creating significant volume or noticeable lifting.
It has the ability to stimulate collagen, but not as intensely as Sculptra or Profhilo.
Must be injected by an expert physician who understands its properties and appropriate injection techniques.

Want to Stimulate Collagen? Should You Choose Sculptra or Skin Boosters Like Profhilo, Definisse Hydrobooster? A Deep Dive Answer from Dr. Nono!

The answer to this question is not a definitive statement of which is "better" in all cases. Instead, it's about choosing what is "more suitable" for each individual's primary concerns and goals! The fact that each type of Biostimulator helps to "stimulate collagen" is merely a fundamental "mechanism." However, the final results obtained from this stimulation differ significantly. It's like building "factories" (stimulating Fibroblasts) that are similar, but each factory might specialize in producing different "products" (various types of collagen, elastin, HA) and using them for different "purposes" (creating volume, rejuvenating skin quality, providing hydration).

Let's delve into a detailed comparison of Sculptra with Profhilo and Definisse.

Sculptra: The Expert in "Creating Volume" and "Enhancing Core Structure" with Type I Collagen!

When it comes to collagen stimulation with the goal of "restoring lost volume" and "strengthening the skin's core structure," Sculptra is truly an outstanding leader.

Mechanism of Collagen Stimulation Sculptra excels at stimulating Fibroblast cells to produce a large amount of Collagen Type I.

Why Type I?

Collagen Type I is like the "main pillars" and "load-bearing beams" of the skin's structure. It's the type that provides strength, firmness, and volume. The fact that Sculptra specifically focuses on stimulating this type of collagen makes it highly effective in restoring volume lost due to aging or the breakdown of subcutaneous fat, and in genuinely strengthening weakened skin structures.

Results from Collagen Stimulation by Sculptra

Natural Restoration of Lost Volume: The newly created Collagen Type I will gradually fill in volume in areas where tissue has sunken, making the face appear fuller, plumper, and naturally younger. This is not a direct filling with external substances.
Strengthening and Supporting Skin Structure: Strong Collagen Type I will help support skin structures weakened by sagging, making the skin appear firmer and providing a subtle lift in the injected areas. It's like building a stronger "foundation" and "steel frame" for the building.
Long-Lasting Results: Because Sculptra stimulates the production of Collagen Type I, which is a long-lasting core structure, the results last longer than skin-focused Biostimulators or common fillers. On average, results last 1-2 years, or potentially even over 2 years.

Sculptra is suitable for

Those with clear facial volume loss (e.g., hollow cheeks, sunken temples, deep eye hollows), those who want to rejuvenate skin structure to be strong from within in the long term, those who desire very natural and sustainable results, and those who can wait for the results to gradually appear.

Profhilo: Awakening the Power of Skin Quality... Stimulating Collagen, Elastin, and HA Comprehensively!

Mechanism of Collagen and Other Substance Stimulation Profhilo doesn't focus solely on Type I collagen. Instead, its active ingredient, the HA Complex, stimulates Fibroblasts to produce collagen (both Type I and Type III), elastin, and Hyaluronic Acid (HA) that the body creates itself. This mechanism emphasizes "dermal remodeling" to make the skin stronger, more elastic, and generally more hydrated.

Results from Profhilo Stimulation

Overall Skin Quality Rejuvenation: It makes the skin appear plump, hydrated (Hydro Effect), slightly firmer (Lifting Effect), elastic, and glowing naturally. It doesn't focus on significant volume enhancement but improves overall skin health. It's like "renovating" the interior of a building, improving the surfaces and walls to look smoother, more flexible, and hydrated.
Addressing Dry, Dehydrated Skin and Fine Lines: Skin that has been rejuvenated with collagen, elastin, and HA will appear plump and smooth, with fine lines looking shallower.

Profhilo is suitable for

Those whose primary concern is skin quality, such as dry, dull, inelastic skin with fine lines across the face. It's for those who want their overall skin to look healthier and slightly firmer.

Definisse Hydrobooster: Boosting Hydration... with "Supplemental" Collagen Stimulation!

Mechanism of Collagen and Other Substance Stimulation Definisse Hydrobooster contains the active ingredients Non-Cross-linked HA + Glycerol. Its primary mechanism is to provide deep hydration. It also has the property of stimulating Fibroblast cells to produce collagen to a certain extent (less than Sculptra or Profhilo).

Results from Definisse Hydrobooster Stimulation

Primarily Hydrated and Glowing Skin: It mainly focuses on hydration, making the skin appear distinctly plump, firm, and dewy.
Slight Firming and Reduced Fine Lines: This comes from both the plumping effect of hydration and the supplemental collagen stimulation.

Definisse Hydrobooster is suitable for

Those whose primary concern is very dry, dehydrated skin, dull skin, or fine lines caused by dehydration. It's for those who want a high-quality skinbooster that offers more than just hydration.

A Deep Dive Answer from Dr. Nono: Which One to Choose? It Depends on the "Problem," Not Just "Collagen Stimulation" Alone!

Therefore, the answer to the question of whether to choose Sculptra or skin boosters like Profhilo/Definisse Hydrobooster to stimulate collagen doesn't just depend on which one stimulates collagen. Instead, it hinges on "what results you desire" and "what your primary concern is."

If your main concern is "clear Volume Loss"

(e.g., hollow cheeks, sunken temples) and you want to restore the skin's "core structure" to be strong again, with natural-looking volume that lasts very long: Sculptra is the most suitable option. This is because it focuses on creating Type I collagen, which is the main structural component.

If your main concern is "skin quality"

(e.g., dry, dull skin, lack of elasticity, fine lines) and you want your overall skin to appear "plump, hydrated, firm, and glowing" naturally, emphasizing improved skin texture: Profhilo or Definisse Hydrobooster might be more on-point choices.

Profhilo: Suitable for those who want to rejuvenate overall skin quality across the entire face and neck, desiring plumpness, firmness, and a natural glow from within.
Definisse Hydrobooster: Suitable for those who prioritize intense hydration, have very dry and dehydrated skin, want their skin to look plump and dewy, with the added benefit of a certain level of collagen stimulation.

Clear Comparison from the Perspective of Collagen Stimulation and Subsequent Results:

Although Profhilo and Definisse Hydrobooster are categorized as "skin boosters" and possess properties that provide hydration along with collagen stimulation, both products have slightly different strengths and roles. I will summarize them for easy understanding:

Property/Difference	Profhilo (Profhilo)	Definisse Hydrobooster (Definisse Hydrobooster)
Active Ingredient	100% highly pure HA Complex (High-molecular-weight and Low-molecular-weight HA thermally linked)	Non-Cross-linked HA + Glycerol
Primary Mechanism	Dermal Remodeling: Complete restructuring of the skin in the dermal layer, emphasizing the stimulation of collagen (Type I, III), elastin, and self-produced HA.	Intense Hydration: Provides deep and long-lasting hydration, along with a certain level of collagen stimulation.
Collagen Stimulation Properties	Outstanding and intense: Effectively stimulates Fibroblasts over a wide area.	Supplemental stimulation: Primarily focuses on hydration; collagen stimulation is at a certain level.
Emphasized Results	Overall skin quality (Skin Quality): Plump, firm, elastic, radiant skin, with a subtle "Lifting Effect."	Hydration and radiance (Hydration & Radiance): Dewy skin, plump, reduces fine lines caused by dry skin. May feel slightly firmer.
Injection Technique	BAP (Bio Aesthetic Point) Technique: 5 points per half-face (10 points total), focusing on widespread distribution.	Multiple Micro-injections scattered across the desired area, or in specific points like under the eyes.
Recommended Areas	Full face, neck, back of hands, upper arms	Full face, under-eye, neck, hands
Number of Sessions (Initial)	2 sessions, 1 month apart	2-3 sessions, 3-4 weeks apart
Specific Advantages	"Glass Skin" effect, internal skin restructuring, very natural results, longer-lasting.	Emphasizes hydration, good for reducing superficial wrinkles, suitable for those who need rapid skin hydration, can be safely injected under the eyes.

Not the Same as Conventional Fillers, and Selection Requires an Expert Physician!

The decision of which type of Biostimulator to choose, or whether to combine it with other programs for the best results, must rely on a thorough assessment of your skin condition, your true concerns, your expectations, and your lifestyle by an experienced physician who deeply understands Biostimulators! At Entrio Clinic, an aesthetic clinic in Ratchaprasong, we offer a variety of Biostimulators, along with a team of expert physicians ready to provide detailed consultations.

Why Choose a Biostimulator Program at Entrio Clinic, Ratchaprasong Aesthetic Clinic? "Dr. Nono Challenges You to Experience" Quality and Results!

At Entrio Clinic Ratchaprasong, we are truly committed to providing the best for everyone. We carefully select standard-certified Biostimulators, offer a variety of options, and ensure care is provided by experienced physicians who deeply understand the differences and mechanisms of each product. We are ready to meticulously assess your concerns and design a Personalized Treatment Plan, whether it involves choosing Sculptra, Profhilo, Definisse Hydrobooster, or a Combination Therapy. Our goal is to help you achieve youthful, natural-looking skin that perfectly meets your needs.

"Dr. Nono Challenges You to Experience" the quality and results for yourself!

If you are ready to invest in sustainably youthful, healthy skin with a diverse and standard-certified Biostimulator Program, along with personalized care from experienced physicians, Entrio Clinic, Ratchaprasong Aesthetic Clinic, welcomes you! Consulting with an experienced physician is the most crucial first step.

Summary from Dr. Nono's Heart: Biostimulator Program – Your Opportunity for Youthful Skin at Entrio Clinic Ratchaprasong

Biostimulators are truly amazing innovations that naturally stimulate collagen and elastin, rejuvenating skin from within for lasting youthful results. Choosing the right Biostimulator depends significantly on your concerns and goals. Both Sculptra, which focuses on volume/structure, and Profhilo/Definisse Hydrobooster, which emphasize skin quality/hydration, each have distinct strengths and roles.

Come visit us at Entrio Clinic Ratchaprasong so I can thoroughly assess your skin concerns and design the most suitable Biostimulator Program or Combination Therapy for you. Our goal is for you to achieve truly beautiful, healthy, and youthful skin.

Entrio Clinic - Refined Aesthetic Experience

"We believe that true beauty comes from good skin health and an understanding of science."

📍 Location: https://maps.app.goo.gl/X9WpN51pnK5otKip8

4th Floor, Erawan Bangkok Building, Ratchaprasong Intersection (behind the Erawan Shrine), Bangkok.

💬 Line: @entrioclinic or click bit.ly/EntrioLine

📞 Tel: 097-154-2222

🌐 Website: entrioclinic.com

💻 Facebook: facebook.com/EntrioClinic

📷 Instagram: entrioclinic or click instagram.com/entrioclinic/